Pathways
Tumor Escape Mechanisms
Description:
Tumour cells characteristically provides their own growth signals, and ignore growth-inhibitory signals, avoid cell death, replicate without limits, sustain angiogenesis, and invade tissues through basement membranes and capillary walls. Whereas cancer immunosurveillance predicts that the immune system can recognize precursors of cancer and, in most cases, destroy these precursors before they become clinically apparent. But sometimes tumour cells use to escape these innate and adaptive immune responses by immunoselection (tha...
References:
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Cancer Immunosurveillance by T Cells.
Int Rev Cell Mol Biol. 2019;342:149-173. doi: 10.1016/bs.ircmb.2018.08.001. Epub 2018 Oct 11. -
Antigen processing and immune regulation in the response to tumours.
Immunology. 2017 Jan;150(1):16-24. doi: 10.1111/imm.12675. Epub 2016 Oct 12. -
Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity.
Front Immunol. 2015 Sep 22;6:488. doi: 10.3389/fimmu.2015.00488. -
Cellular and molecular mechanisms in cancer immune escape: a comprehensive review.
Expert Rev Clin Immunol. 2014 Jan;10(1):41-62. doi: 10.1586/1744666X.2014.865519. Epub 2013 Dec 10.
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